![]() ![]() Our data underscore a physiological role for taste perception in postprandial glucose responses, suggesting sweeteners should be consumed in moderation.Įven though LCSs have a negligible calorie content, data from animal models and human cell lines suggest that they are metabolically active, presumably by interaction with sweet taste receptors. Sucralose did not affect glucose rates of appearance or β-cell function in either weight group. Sucralose ingested (but not sham-fed) increased S I in normal-weight participants by 52 ± 20% but did not affect S I in participants with obesity. Sham-fed sucralose similarly decreased insulin concentrations within 60 min of the OGTT in both weight groups. In contrast, the insulin response to sucralose ingestion differed depending on the presence of obesity: decreased within 20–40 min of the OGTT in normal-weight participants but increased within 90–120 min in participants with obesity. Compared with water, sucralose ingested (but not sham-fed) resulted in a 30 ± 10% increased glucose area under the curve in both weight groups. Indices of β-cell function and insulin sensitivity (S I) were estimated using oral minimal models of glucose, insulin, and C-peptide kinetics. ![]() Participants (10 with normal weight and 11 with obesity) without diabetes underwent three dual-tracer OGTTs preceded, in a randomized order, by consuming sucralose or water, or by tasting and expectorating sucralose (e.g., sham-fed sweetness control). Here, we tested the hypothesis that sucralose differentially affects metabolic responses to labeled oral glucose tolerance tests (OGTTs) in participants with normal weight and obesity. ![]()
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